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CHROMATIN AND EPIGENETIC REGULATION
Our mission is to implement innovative scientific approaches and develop useful tools, reagents and therapeutics that advance our understanding of chromatin function in human health and disease. Central to the success of this mission is our dedication to the education and training of scientists to prepare them to become leaders in the scientific community.
Featured News
4 April 2019 Blocking epigenetic “Swiss army knife” may be a new strategy for treating colorectal cancer
5 Dec. 2018 Teaming up to accelerate scientific discovery
20 Sept. 2017 $2.375 million federal award to study epigenetic control systems, inform drug discovery
6 Aug. 2015 Meet the author: Scott Rothbart
Molecular Cell
FEATURED PUBLICATIONS
Kong X*, Chen J*, Xie W* et al. 2019. Defining UHRF1 domains that support maintenance of human colon cancer DNA methylation and oncogenic properties. Cancer Cell.
Cornett EM et al. A functional proteomics platform to reveal the sequence determinants of lysine methyltransferase substrate selectivity. Sci Adv.
Shah RN et al. Examining the roles of H3K4 methylation states with systematically characterized antibodies. Mol Cell.
Proud to anchor this amazing team who are accomplishing great things at Van Andel Institute
Scott and Rob are having fun in Atlanta at National Conference on Undergraduate Research recruiting for Van Andel Institute Grad School. Searching for future leaders in biomedical research at the Atlanta Braves game!
Our new paper is out today in Cancer Cell (Cell Press)!
Blocking epigenetic “Swiss army knife” may be a new strategy for treating colorectal cancer - VAI
www.vai.org
GRAND RAPIDS, Mich. (April 4, 2019) — A new study out today in Cancer Cell shows that blocking specific regions of a protein called UHRF1 switches on hundreds of cancer-fighting genes, impairing colorectal cancer cells’ ability to grow and spread throughout the body. “Colorectal cancers are a ...