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CHROMATIN AND EPIGENETIC REGULATION
Our mission is to implement innovative scientific approaches and develop useful tools, reagents, and therapeutics that advance our understanding of chromatin function in key areas of biomedical research. Central to the success of this mission is our dedication to the education and training of scientists to prepare them to become leaders in society.
News
Revealing the root causes of colon cancer: Three questions for Dr. Ali Lanctot Chomiak
VAI Voice
How getting back to the basics can improve human health
VAI Voice
20 Sept. 2017 $2.375 million federal award to study epigenetic control systems, inform drug discovery
Making an early impact: Three questions for Dr. Rochelle Tiedemann
VAI Voice
3 Nov. 2016 New computational tool may speed drug discovery
7 Sept. 2016 The whole of epigenetic regulation may be more than the sum of its parts
Let’s get physical – adventures in the dry lab
VAI Voice
Meet the author: Scott Rothbart
Molecular Cell
23 July 2015 New antibody specificity portal bolsters biomedical research reliability
1 April 2015 Van Andel Research Institute’s center for epigenetics adds new assistant professor
FEATURED PUBLICATIONS
Vaughan RM et al. Chromatin structure and its chemical modifications regulate the ubiquitin ligase substrate selectivity of UHRF1. Proc Natl Acad Sci U S A.
Vaughan RM et al. Comparative biochemical analysis of UHRF proteins reveals molecular mechanisms that uncouple UHRF2 from DNA methylation maintenance. Nuc Acids Res
Veland N et al. The arginine methyltransferase PRMT6 regulates DNA methylation and contributes to global DNA hypomethylation in cancer. Cell Rep
Harrison J et al. Hemi-methylated DNA regulates DN methylation inheritance through allosteric activation of H3 ubiquitylation for UHRF1. eLife
Cornett EM et al. Substrate specificity profiling of histone-modifying enzymes by peptide microarray. Methods Enzymol
Dickson BM et al. ArrayNinja: An open source platform for unified planning and analysis of microarray experiments. Methods Enzymol
Rothbart SB et al. An interactive database for the assessment of histone specific antibody. Mol Cell
Dr. Rothbart and Ph.D. program recruiter Christy Mayo are in San Antonio at #SACNAS2018 representing Van Andel Institute Graduate School! Learn more about our program here: vaigs.vai.org/
Every hour is happy hour in the Rothbart lab. Celebrating Evan’s new paper! Stay tuned for details...
With scientists at EpiCypher Inc. and The University of Chicago, we’ve been applying next-generation chromatin biochemistry tools toward the characterization of antibodies used for epigenetics research. Our findings were published today in Molecular Cell!This video abstract refers to the following paper published in Mol Cell: Examining the roles of H3K4 methylation states with systematically characterized ant...