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CHROMATIN AND EPIGENETIC REGULATION
Our mission is to implement innovative scientific approaches and develop useful tools, reagents, and therapeutics that advance our understanding of chromatin function in key areas of biomedical research. Central to the success of this mission is our dedication to the education and training of scientists to prepare them to become leaders in society.
News
How getting back to the basics can improve human health
VAI Voice
20 Sept. 2017 $2.375 million federal award to study epigenetic control systems, inform drug discovery
Making an early impact: Three questions for Dr. Rochelle Tiedemann
VAI Voice
3 Nov. 2016 New computational tool may speed drug discovery
7 Sept. 2016 The whole of epigenetic regulation may be more than the sum of its parts
Let’s get physical – adventures in the dry lab
VAI Voice
Meet the author: Scott Rothbart
Molecular Cell
23 July 2015 New antibody specificity portal bolsters biomedical research reliability
1 April 2015 Van Andel Research Institute’s center for epigenetics adds new assistant professor
FEATURED PUBLICATIONS
Vaughan RM et al. Comparative biochemical analysis of UHRF proteins reveals molecular mechanisms that uncouple UHRF2 from DNA methylation maintenance. Nuc Acids Res
Veland N et al. The arginine methyltransferase PRMT6 regulates DNA methylation and contributes to global DNA hypomethylation in cancer. Cell Rep
Harrison J et al. Hemi-methylated DNA regulates DN methylation inheritance through allosteric activation of H3 ubiquitylation for UHRF1. eLife
Cornett EM et al. Substrate specificity profiling of histone-modifying enzymes by peptide microarray. Methods Enzymol
Dickson BM et al. ArrayNinja: An open source platform for unified planning and analysis of microarray experiments. Methods Enzymol
Rothbart SB et al. An interactive database for the assessment of histone specific antibody. Mol Cell
Two new PhD students joined the lab last week. Welcome to the group Bailey and Eric! Visit our team page to learn more about us.
rothbartlab.vai.org
Rothbart Laboratory team: Scott Rothbart, Evan Cornett, Brad Dickson, Alison Lanctot, Kevin Shaw, Rochelle Tiedemann, Robert Vaughan & Amy Nelson.
Like so many things in life, our epigenetic inheritance is greater than the sum of its parts. That's the takeaway from our latest paper, published in Nucleic Acids Research and highlighted today on Van Andel Institute's blog. Read the post by clicking below!
There is no “I” in “team” - VAI
vai.org
How the smallest components of life work together to manage our epigenetic inheritance When it comes to understanding the intricate genetic architecture that makes us human, the old adage holds true — the whole is greater than the sum of its parts. That’s according to new findings published rece...
Rothbart Laboratory at VARI shared Van Andel Institute's post.
Are you a Ph.D. student interested in learning more about epigenomics? The application period for our one-week workshop, Epigenomics at VARI, is now open! Learn more about the curriculum, the speakers and the application process here: